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Jerry's avatar

Dr. Malone's name is on all the early patents for the mRNA platform. According to his wife, Dr. Malone was the first to realize that the mRNA transfections were causing an immune response. Malone summarized his contributions to the technology at his substack, here:

https://rwmalonemd.substack.com/p/bushwhacked-by-alex-berenson-on-fox

He also points to an essay by his wife, who documents the precise timeline of the discovery and Dr. Malone's role. Specifically, according to Dr. Jill Glasspool Malone:

https://static1.squarespace.com/static/617d909092cd2314e37ebe67/t/617de3cd04bffe53342539cb/1635640269719/Jill%27s+letter+about+RNA+vaccination+generic+v5+June2021.pdf

"At the Salk Institute/UCSD, he [Robert Malone] did his thesis work under Dr. Inder Verma on RNA structure and DNA/RNA gene transfer. The first realization that DNA in itself can produce an immune response was when Robert began collaborating with a post-doc in Verma’s lab by the name of Dr. Daniel St. Louis in 1987. Dr. St. Louis was working on a hemophilia gene therapy model in rabbits using retro-viral transduction techniques. Dr. St. Louis kept having gene expression stop at about two to three weeks post-treatment and he was sure that this loss of gene expression had to do with the promoter he was using. Dr. St. Louis talked with Robert Malone and Robert got obsessed with this puzzle and spent day and night poring over Dan's data, medical texts and journals. Then, he had a brainstorm. What was going on was that immune responses were shutting down gene expression. It had nothing to do with the promoter Dr. St. Louis was using. He presented all of his work and thoughts to Dr. St. Louis. This was the intellectual exercise that led to Robert discovering RNA and DNA vaccines at that time. Note that Robert is acknowledged in the St. Luis paper (St Louis D, Verma IM. An alternative approach to somatic cell gene therapy. Proc Natl Acad Sci U S A. 1988 May;85(9):3150-4. doi: 10.1073/pnas.85.9.3150. PMID: 3283738; PMCID: PMC280161).

"In fact, Robert talked with me extensively about using retroviral vectors for genetic vaccination during this time, but thought that the dangers of retroviral vectors were too great and that the FDA would not allow for this to be licensed. However, this intellectual challenge led to this idea of using DNA and RNA delivery for vaccines. By spring 1988, his ideas about DNA and RNA vaccination were cohesive and formed the basis for the research plan that Vical later developed.

"As a witness to what these ideas represented and the timeline of when the ideas and experiments were performed, I know that Robert was obsessed with gene transfer and immune responses long before he went to work for Vical in 1989. Robert’s first paper on RNA/cationic liposome transfection (PNAS) (which now has 747 citations) as well as published papers on RNA/DNA/cationic liposome transfection and embryonic transfection, were researched and written in 1988. I even have a journal entry dated in 1988, where I write briefly of Robert’s ideas regarding genetic vaccination."

I agree that Malone did not invent the idea of using injected mRNA to create a transfection, nor did he invent the use of a lipid container for the mRNA -- although he was certainly involved in the lab work to implement these inventions, and his name is on the patents. His most important claim to fame here, is that he came up with the idea of using the technology for purposes similar to traditional vaccination.

Since all of this happened in 1988, it's also important to note that Dr. Malone has had a distinguished career in vaccine development since then. There is no board specialization or residency in vaccinology, which is a distinct field of endeavor. Malone's education and experience make him an imminently qualified specialist in this field. Malone's CV is at this link:

https://www.thethinkingconservative.com/wp-content/uploads/2021/07/Robert-W-Malone-CV-July-2021.pdf

Which brings us to Dr. Malone's claims in the video posted to "The Kick Them All Out Project". In this video, Dr. Malone says that the UK is "normalizing" broad-based testing for acquired immune deficiency syndrome (AIDS). This syndrome is characterized by high rates of opportunistic infectious diseases and cancers. Malone goes on to say that a wide variety of evidence is pointing to alarming increases in cancer rates in populations subjected to the covid-19 injections. This includes data from Ryan Cole; from the DOD data released by Thomas Renz; and actuarial data released by multiple insurance companies.

Dr. Patmas, how do you know that the injections are safe, and don't cause AIDS or cancer? Where is your data to the contrary?

Why is it unprofessional conduct, to discuss data? Isn't this a constitutionally protected free speech right?

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Michael Patmas, MD's avatar

All wrong. Read my posts. Malone name appears last or next to last on 14/15 patents. Felgner is the primary inventor on most. As for his claim of invention, his own 1989 paper refutes that. He cites Felgner (re #10) and thanks Syntex for their "generous" gift of Lipofectin. As for foreign DNA eliciting an immune response, duh? Of course it does. Ever heard of autoimmune disease? That's basic immunology. A distinguished career? He was unknown prior to his antivaxx coming out party. I attend UCSF CME events regularly. At one a group of the most distinguished ID docs in the country all commented they had never heard of him until Rogan. As for safety of the vaccines. that has been well documented. There is no evidence that they cause AIDS, Cancer, Autism, or global warming. Pulling wild stuff out of hat isn't science, its disinformation. As for "freedom of speech", medical practice acts are very clear as is direction from the Federation of State Medical Boards: “Physicians who generate and spread COVID-19 vaccine misinformation or disinformation are risking disciplinary action by state medical boards, including the suspension or revocation of their medical license. Due to their specialized knowledge and training, licensed physicians possess a high degree of public trust and therefore have a powerful platform in society, whether they recognize it or not. They also have an ethical and professional responsibility to practice medicine in the best interests of their patients and must share information that is factual, scientifically grounded and consensus-driven for the betterment of public health. Spreading inaccurate COVID-19 vaccine information contradicts that responsibility, threatens to further erode public trust in the medical profession and puts all patients at risk.” Physicians are OBLIGATED to share evidence based data from high quality peer reviewed research that is CONSENSUS-DRIVEN, aka Guidelines from the experts. In this case IDSA guidelines. Physicians DO NOT make up their own guidelines. If they don't know what to do they go to UPTODATE.com for the answers. Under no circumstances is it considered professional for a physician to disseminate junk science. Publicly claiming the mRNA vaccine causes AIDS, Cancer or Ebola is totally unprofessional and erodes confidence in public health efforts. Malone did not complete post graduate medical education (residency) and is neither board certified nor board eligible in any clinical specialty including pathology. He did not do an infectious disease fellowship hence he is not an infectious disease doctor. He has no hospital medical staff membership or clinical privileges. I am sure his wife loves him dearly but she may be just a tad biased. My mommy thinks I am the best doctor since Ignaz Semmelweiss. But what I really want to know is how he managed to go from a PGY2 to Assistant Professor, Founder and Director of the Gene Therapy Program at UC Davis in 1993. That is a truly astonishing promotion considering he did even finish a residency program! Surely, one would expect some mention of it the UC Davis Archives and Catalogs.

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Jerry's avatar

Dr. Patmas, none of this is very convincing.

If you're not impressed that Malone's name appears last on most of those patents, you should be. In general, the first author is the senior managing scientist of the lab, while the last author is the one who did the bulk of the work, and/or came up with the ideas.

Most scientific discoveries seem obvious in retrospect. But can you show me any patent or scientific paper prior to Malone's work in 1988, where someone states that an mRNA transfection induces an immune response?

Malone's CV states: "Dr. Malone has approximately 100 peer-reviewed publications and published abstracts and has about 12,000 citations of his peer reviewed publications and patents, as verified by Google Scholar. His google scholar ranking is “outstanding” for impact factors. He has been an invited speaker at over 50 conferences, has chaired numerous conferences and he has sat on or served as chairperson on numerous NIAID and DoD study sections."

Do you dispute any of that? If none of your ID friends at UCSF had ever heard of him, it demonstrates one of two things, or perhaps both: (1) infectious disease doctors are not vaccinologists, and don't read in that field. Or, (2) in spite of their education, these individuals pride themselves on their ignorance.

Ultimately, all this attempt to discredit Dr. Malone is a red herring. Ad hominem argument is a form of logical fallacy. Malone is talking about data. Where is your data?

You say that "the safety of vaccines is well documented." We are not talking about vaccines in general, we are talking about the experimental covid-19 mRNA transfections. Your snide reference to global warming is insulting and off-topic.

The Federation of State Medical Boards is an advisory non-profit. It is not a governmental or quasi-governmental entity, and has no power to force state medical boards to adopt its policies.

But the threat to individual practitioners' freedom of speech, and their licenses, is very real. And this leads to a severe problem: how can a non-specialist know if a consensus among specialists really exists, if any dissent is suppressed by gag orders?

Your conception of the role of doctors and researchers is demeaning. "Just go to UPDATE.COM for answers??" What do you need credentials or education, if the end result is that your practice is dictated by some website?

Unfortunately, many doctors do their work in exactly this cookie-cutter fashion. And they're being replaced by RN's with masters' degrees, who are gradually taking over PCP work from board certified family practitioners. They might as well be replaced by computers.

No mention of Malone at UC Davis? Your article "The incredible, fantastic, amazing, unbelievable accomplishments of Dr. Robert W Malone" states, to the contrary, that Malone was listed as an adjunct assistant professor from 1995-1997. If you don't believe that Dr. Malone founded a Gene Therapy Program at Davis, why don't you ask him? It seems completely plausible to me, that this wasn't recorded in archives and catalogs from thirty years ago.

You don't even understand the difference between someone's wife, and his mother. In this day and age, it's not an easy thing to stay married to your childhood sweetheart. If Dr. Malone were a swindler or rogue, Dr. Jill would have left him long ago.

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Michael Patmas, MD's avatar

Read my article about proof that he did not invent the vaccine or the technology. If that evidence does not persuade, you are not objective.

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Michael Patmas, MD's avatar

You confuse author name order on patients with that od scientific articles. With patents, the primary inventors name in first. the names proceed thereafter by the significance of their contribution. Malone got his mane on them because he was the STUDENT working in the lab. As for DNA and RNA autoimmunity. C',mon man, there is those totally lacking in clinical education get confused. I have been a doctor for 41 years. We knew decades ago that autoimmune diseases involve immune responses to DNA and RNA. https://pubmed.ncbi.nlm.nih.gov/18071658/. One GOOD paper is worth more than 100 pieces of junk, no matter how many times they cited. Malone DID write a really good paper in PNAS in 1989, the one wherein he acknowedges Felgner at the inventor of lipofection. You should read it sometime. As for folks at UCSF, they are not alone. No one had heard of him. He has a pathetic acdemic pedegree. Adjunct assistant professor! Those titles are given to docs aren't really faculty members. One year here. Two years there. As for data, its all right there in the NEJM. As for UTD, you display utter ignorance of what that tool is. It is the online clinical decision support tool used at every major acadmemic medical center, the single best source of quality data. I don't need to discredit Malone. Lots of folks are on to him now. Its only a matter of time before his 15 minutes is up. His CV is so full of red flags that so many people are investigating him now. I don't need to. Keep watching. He is about to be exposed and a lot of people will be very embarrased when they find out how they took his CV at face value. Can you imagine, a RESIDENT physician, a PGY2 being named Founder and Director of the Gene Therapy Program at a major academic medical center. This is absurd on its face. No mention of any such center at UC Davis between 93-97 anywhere. Their GTP was founded in 2020. He is a graduate of MSU..."make stuff up".

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Jerry's avatar

Haha, I got it backwards on the author order on scientific papers, and you didn't call me on it. The last author is more likely to be the PI or lab head, and it's obvious that didn't apply in Malone's case. My bad.

Are patents different? Let's consult a law firm. According to "upcounsel.com" (https://www.upcounsel.com/patent-inventor-name-order):

"An inventor is considered anyone that helped contribute to the conception of the invention. By law, an inventor is not considered someone who only contributes capital to the invention or someone whose only contribution is to reduce it to practice. For example, if an individual's only involvement was to prove that the invention works by carrying out tests without actually contributing to the concept, then that person wouldn't be considered the inventor."

Which seems to rule out your view that Malone's role was solely a matter of implementation, as a student in the lab. Also, Malone doesn't need to be the sole or primary inventor, in order to claim that he played a role as an inventor of the technology.

Furthermore:

"The way inventors' names are listed on patents and research publications will often vary. ... Attorneys, companies, and agents all may have their own standard for how the name order is determined. For example, a university may insist that department chairs are listed first, followed by professors, assistants, adjunct professors, and then interns and students."

So perhaps we both are jumping to conclusions here? Maybe Malone was listed as the last author on the patents, as a matter of rank rather than contribution.

Davis didn't create a Gene Therapy Program until 2020? Behind the times much?? Malone didn't say he was "named" a Founder and Director of a Gene Therapy Program. He says he directed and founded a gene therapy program. Maybe he didn't attract a lot of support. I give him credit for taking initiative.

"C'mon, man"?? Channeling Biden, eh? C'mon, man, if you knew this 41 years ago, why isn't it your name on those patents? And if you're trying to prove that everyone knew this by 1977 when you were in medical school, why are you linking to a paper written in 2008?

"The data is all there in the NEJM". You mean the NEJM whose former editor in chief said that "it is simply no longer possible to believe much of the clinical research that is published"?

https://judahstclinic.com/news/2013/12/14/nejm-editor-no-longer-possible-to-believe-much-of-clinical-research-published

You're going to have to do more data analysis than to simply refer to the NEJM. You're still putting 99% of your effort into discrediting Malone, which really doesn't respond at all to his arguments. And your fifteen minutes are almost up, at least with this reader.

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Michael Patmas, MD's avatar

Felgner wrote about mRNA transfection using lipofectin (which Felgner developed) TWO YEARS before Malone went to work in his lab! H only lasted nine after getting caught listing his name first on a patent application. Malone was not the first to suggest it. But he was smart enough to realize how imporatnt it would be.

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